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10.1111/j.1365-2222.2009.03369.x

PZWL Publishing House

2023;41(10):180316.e8

Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling

5 Pharmacological PRMT5/MAT2A inhibition and selectivity for MTAP-deficient cells A limiting factor to targeting PRMT5 directly is its important role in normal tissue function, but a synthetically lethal interaction with an MTAP -negative background should, in principle, provide a suitable therapeutic window
