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Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral central nervous system infections

PMID: 39201690 J Drug Deliv Sci Technol2024 Oct

Single-cell barcoding and dynamical systems approaches further support this view, showing that aged MuSCs follow the same differentiation trajectories as young cells but stall near commitment checkpoints, suggesting delayed progression rather than lineage restriction

J Cardiovasc Surg

In several meta-analyses, UPT was found to be the most effective small molecule drug for inducing clinical remission and clinical response, but it had the highest incidence of adverse events in patients with moderate to severe UC [12, 179]

Over a larger dose range, the relationship between cell killing and dose is more complex and is described by three different components: an initial slope (D 1 ), a final slope (D o ), and the width of the shoulder (n, the extrapolation number) or Dq, the quasi-threshold dose (Fig