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Indeed, their deregulations have a direct impact on nutrients uptake, gut functionality, and microbiome, and, importantly, pancreatic enzymes alterations are directly associated to adipose tissue wasting, making it an early event in pancreatic cancer-associated cachexia (Danai et al., 2018)

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Gregorios JB, Mozes LW, Norenberg MD (1985a) Morphologic effects of ammonia on primary astrocyte cultures

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