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For example, in human fibroblasts undergoing senescence induced by transient activation of p53 with Nutlin3a, lysosomal damage led to H + overflow, inducing more intracellular acidosis than in uninduced cells

doi: 10.1097/RLU.0000000000005562 Ranes Jennifer Marie Catherine

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However, their reliance on non-renewable carbon sources, energy-intensive thermal activation of charcoal, and high costs have prompted the scientific community to seek cost-effective and sustainable alternatives

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Additionally, the expression of antioxidant paraoxonase (PON-1) was identified to be significantly decreased