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At concentrations above 1000 mol/L, vitamin C is toxic to some cancer cells but not to normal cells in vitro

In addition, redox conditions vary between cell-based/organoid cultures and in vivo conditions, which is illustrated by the frequent requirement for system x c - in cell culture, whereas system x c - knockout mice are viable (McCullagh and Featherstone, 2014)

10.1016/S1474-4422(10)70245-3 379 RouaultT

Overall, there were no differences in ECAR in any condition or in response to injection of glucose (G), oligomycin (O), or 2 deoxy-D-glucose (2DG) (see the cartoon in Fig

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2-ATF 4 pathway

Endocrinology 144(2): 544-551