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Additionally, animal studies such as the one by Gurger et al

Importantly, people who already have liver disease are at a higher risk of liver damage from acetaminophen because they likely arent producing enough glutathione
doi: 10.1189/jlb.1208759

Braaks hypothesis suggests that the -synuclein pathology begins in the ENS and then migrates to the brain, passing through the brainstem, midbrain, basal forebrain, and finally the cortical areas [118, 119]

[PubMed] [Google Scholar] 105.Zheng H, Zhang L, Bai X, Zhu J, Liu S, Ke Y, Lin Q, Yuan Y, Ji T

Autophagy 11 , 17451759 (2015)