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Statistical methods All statistical analyses were performed based on the intention-to-treat (ITT) principle, in which missing values were imputed using multiple imputations

Migraine associates with several other effects and phenomena, resulting in lower glucose levels, or impeding its uptake and utilization, indicating a brain energy deficit reported in migraineurs, such as impaired glucose transport across the blood-brain barrier (BBB), hypoxia, and hypoglycemia [8,37,38,39]

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(2) This may ultimately lead to a reduction in weight through increased calories burned during exercise