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Small molecule inhibitor of LSD1 (Parnate), EZH2 (DZNep), and DOT1L (EPZ004777) promoted somatic reprogramming efficiency (Martinez-Gamero et al., 2021
In fungi the metabolic gene clusters are often associated with fungal virulence, and evolutionarily with pathways conferring some advantage over competitors
[PubMed] [Google Scholar] 148.Pinder R.M
Gen Comp Endocrinol (2018) 255:90101
Science 334 , 678683 (2011)
Accordingly, loss of SIRT4 enhances glutamine-dependent proliferation and genomic instability, which simultaneously contribute to tumorigenesis 151
