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This condition has been associated with maternal riboflavin deficiency, and supplementation with oral riboflavin led to the resolution of the clinical symptoms [70] A mitochondrial FAD transporter deficit has been reported in two cases of individuals who had mutations in both copies of the SLC25A32 gene (OMIM #616839), which encodes the mitochondrial FAD transporter

The average fluorescence intensity of the cells was analyzed using Image-Pro Plus software (Media Cybernetics Inc.)

In some embodiments, the otic formulation or composition comprises between about 0.001% to about 99.99% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

The graph below shows the increase in glutathione levels experienced by four groups