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For the T1D EWAS, we also applied the limma pipeline (lmFit and eBayes), fitting a multiple linear model that adjusted for multiple confounders, including age, sex, sample timepoint, technical factors such as chip and position, and the 12 estimated immune cell fractions, to identify T1D-associated DMCs

ICP ICP is a pregnancy-specific liver disease that may lead to adverse fetal outcomes, including preterm delivery, meconium staining of the amniotic fluid, and stillbirth
Association of glutathione S-transferase T1, M1 and P1 polymorphisms in the breast cancer risk: a meta-analysis in Asian population

He Q, Liu M, Huang W, Chen X, Zhang B, Zhang T, et al

Medvedev et al., 2013)

However, these techniques have limitations, such as the inability to distinguish ferroptosis-specific iron from other forms of iron deposition, underscoring the need for further standardization
