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This concept, called ligand-directed vascular targeting, remains an active area of peptide research
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Effect of caffeine on the body fat and lipid metabolism of rats fed on a high-fat diet

Results that develop and improve over 48 weeks

Control group were recruited from healthy persons that matched for age and sex with case group

Clinical trials have utilized doses ranging from 1 mg per day up to 30 mg per day in divided doses for various administration routes