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Despite the benign nature of these tumors, their management can have a very significant impact on quality of life, even in uncomplicated cases

In Sertoli cells the 4 double bond of testosterone is reduced, by the action of steroid 5-reductase, producing dihydrotestosterone (DHT)

This imbalance impairs vasodilation, promotes vasoconstriction, and increases vascular permeability, creating a conducive environment for the infiltration of lipoproteins and immune cells into the arterial wall

[DOI] [PMC free article] [PubMed] [Google Scholar] 121.Neelov I., Popova E., Khamidova D., Tarasenko I

*Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profiles

However, only one of these mutations, K304E accounts for the majority of MCAD mutations identified to date