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A variety of studies have reported that IGF-1 not only affects muscle hypertrophy, but also inhibits muscle protein breakdown, leading to skeletal muscle atrophy [133]
[DOI] [PMC free article] [PubMed] [Google Scholar] 221
Anti-wasting effect Muscle wasting or atrophy, often known as reduction in skeletal muscle mass, is now a frequent hallmark of various chronic disorders, including infectious diseases and cancer (Lenk et al., 2010, Powers et al., 2016, Remels et al., 2013)
10.1016/j.eplepsyres.2020.106469 129
J Translational Med
