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Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)

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Bacteriostatic water is sterile water that contains 0.9% benzyl alcohol in order to stop the growth of any potential bacteria that could contaminate the sterile bacteriostatic water

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The pathogenesis is likely due to a transcriptome change in Propionibacterum acnes , the organism responsible for acne vulgaris