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Indeed, as mitochondrial membrane enrichment in cholesterol was responsible for the decreased mitochondrial membrane fluidity, lovastatin, an inhibitor of hydroxymethylglutaryl coenzyme A involved in cholesterol synthesis, was able to protect hepatocytes from acetaldehyde sensitization to tumor necrosis factor (TNF) (Lluis et al, 2003)
Most of this damage is caused by ROS
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Krusenstjerna-Hafstrm, T
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