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The potential functions of tocochromanol catabolites are under active investigation because they retain their antioxidant activity and are more water soluble than the parent compounds
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doi: 10.1016/s0891-5849(02)00863-8 Kalkan Ucar S, Coker M, Szmen E, Goksen Simsek D, and Darcan S ( 2009 )

[22] The same work parsed the downstream genes carefully and found a split: some responses (such as induction of the survival gene Bcl-XL) were abolished in mice engineered to lack functional IGF-1 receptors on their muscle fibers, while others (such as induction of matrix metalloproteinase-13) persisted even without the receptor

The ability of FGF21 to exert its anti-intoxicant effect can be blocked by interference with the adrenergic receptor system

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