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Notably, in NOD mouse models, autoreactive antibodies directed towards P4Hb were detected before autoantibodies towards insulin (121)

Vega, S., Abian, O

a , Experimental scheme

doi:10.1080/10408390601062054

In the sequenced or combined application, most bioactive compounds had strong antioxidant properties or served as co-enzymes that stimulated the antioxidant defense system, reducing the overproduced ROS and alleviating the abiotic stresses

Furthermore, the escalation of plasmablasts in the bloodstream and plasma cells in the SGs of individuals with SS is positively connected to serum IgG levels, disease activity, and autoantibody positivity (108, 109)