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Figure 3 The Pro- or Anti-Inflammatory Activity of CRP Is Defined by Its Conformation Over many decades, CRP has been studied as both a contributor to and protector from the pathologies associated with disease

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doi: 10.1016/j.jcmg.2018.09.019

doi: 10.1016/j.cub.2020.04.066 113 SzatmariITrcsikDAgostiniMNagyTGurnellMBartaEet al

A critical 2008 study published in Cell Biochemistry and Function demonstrated that pretreatment with carnosine significantly inhibited mast cell degranulation and halted the release of histamine and lactate dehydrogenase during severe pathological stress, confirming its role as an endogenous mast cell stabilizer