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However, if conservative management does not relieve your symptoms, or if your knee becomes unstable, further evaluation may be necessary

10.1016/j.pharmthera.2017.02.014 [DOI] [PMC free article] [PubMed] [Google Scholar] Hao Y., Li H., Ge X., Liu Y., Yin J., Li X., et al

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Vickers et al., 2009

Both play a key role in regulating melanin production and skin cell renewalwhen low, they can trigger uneven pigmentation and dark patches Low Vitamin B12 disrupts DNA synthesis and melanocyte regulation, causing irregular melanin distribution

Early diagnosis and appropriate Vitamin B12 supplementation are essential to restore healthy blood function and prevent long-term complications
