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20 L of plasma was deproteinated and run on two liquid chromatography columns (Hypercarb and Reverse Phase) in both positive and negative modes for a total of 4 sample runs per study sample via liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS)

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Akathisia is commonly associated with LAI and oral antipsychotics 14,15,29,30 and was of interest in this analysis because there is a perception that the total amount of drug administered within 110 days (as in the 1-day regimen) may increase the incidence of akathisia