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We discovered that TAX6/Calcineurin serves as a key component in inhibiting GPCR signaling: while tax6 mutants were unable to generate pulsatile activity and reach exact adaptation in response to the natural stimulus diacetyl (Figs 3 and 4), their calcium dynamics following optogenetic activation was similar to wt worms (Fig 5)

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Corsaro, A., Paludi, D., Villa, V., DArrigo, C., Chiovitti, K., Thellung, S., Russo, C., Di Cola, D., Ballerini, P., Patrone, E., Schettini, G., Aceto, A., & Florio, T

J., Fernandez-Ballart, J

This imbalance can result from increased free radical production, decreased antioxidant defenses, or both [7]