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The affinity of the GHK tripeptide for copper is exceptionally high, and it is this complex that is believed to be the primary biologically active form

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As all these dendritic and spine phenotypes have been observed both by exposing the animal to a stressful situation or by administering corticosterone, it is evident that the stress hormone plays a major role in dendrite and spine remodeling

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In one study, (2) obese experimental murine models were subjected to the peptide for two consecutive weeks