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Thirdly, sub-inhibitory drug exposure can significantly upregulate the expression of ERG family, drug efflux pump genes, and stress tolerance genes in C

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For instance, in a model of APAP-induced liver injury, the protective antioxidant and anti-inflammatory effects of the bioflavonoid naringin are highly dependent on the upregulation of both CHAC2 and NRF2 (Zhai et al., 2022)

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If headaches persist beyond two weeks at conservative doses with proper hydration, consider splitting your dose