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As some of these mediators such as TNF- and IL-1 are further inducing NF-B translocation, this self-amplifying cycle produces even more cytokines, attracting more neutrophils, fostering a stronger pro-inflammatory reaction [140]

At present, glycolytic metabolism alterations and mitochondrial dysfunction of DAA or reactive astrocytes were reported in the contexts of (1) glycolytic metabolism alteration

Cell Stem Cell 18, 2538