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These are just a couple of examples of how naturally-occurring protein tags contribute the appropriate localization and abundance of proteins, and how disease can result when these processes go haywire

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4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2)

The dietary essentiality of arginine in poultry stems from the absence of the enzyme carbamoyl phosphate synthase-I

Stress, overconsumption of alcohol, food intolerance, microbial imbalance and poor nutrition can affect the integrity of the epithelial barrier
