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The landmark Phase IIb clinical trial published in The Lancet (TIPO-1 study) evaluated 203 obese patients randomly assigned to receive tesofensine at doses of 0.25mg, 0.5mg, or 1.0mg daily for 24 weeks alongside an energy-restricted diet

De Flora, A., Guida, L., Franco, L

Thomas SN, Funk KE, Wan Y, Liao Z, Davies P, Kuret J, Yang AJ

Markers of oxidative stress, such as MDA, 8-isoprostane, and protein carbonyls, are elevated in plasma, sputum, and exhaled breath and are linked to the severity of the disease and treatment resistance