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Additional mechanisms involve down-regulation of EGFR expression (transcriptional repression or enhanced proteasomal/lysosomal degradation), interference with membrane lipid-raft localization which hinders receptor clustering and perturbation of adaptor proteins (GRB2, SHC) and downstream pathways (RAS/RAF/MEK/ERK, PI3K/AKT) that lead to lower proliferative and survival signaling ([267] [275],)

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[DOI] [PubMed] [Google Scholar] 108.Miyanaga A., Fushinobu S., Ito K., Wakagi T

The hallucinations stopped after 19 days despite no changes in her medicine