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It is also assumed that cobalamin supplementation is necessary until the symptoms of deficiency disappear (in the case of dietary modification) or must be introduced permanently if the diet does not cover the daily requirement for vitamin B12, which is usually the case when following a vegan/vegetarian diet

The ED 50 for this effect is 0.3840 ng/mL, corresponding to a specific activity is 2.6010 6 units/mg

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In shuttle-saturated cells, reduced flux of pyruvate through the pyruvate dehydrogenase complex and the TCA cycle means less citrate is generated and exported from mitochondria