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Estrogen and progesterone are secreted via the ovaries and uterus and undergo changes during the estrus cycle

Conversely, the inflammation and immune responses triggered by pyroptosis release various inflammatory mediators and cytokines, such as interleukin-1 and interleukin-8, which might promote tumor growth, modify the tumor microenvironment, and contribute to drug resistance (133)

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A system that keeps up
