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Epalrestat was shown to inhibit the homologous enzymes AKR1B1 and AKR1B10 [145,156]
In various conditions with mitochondrial impairment, such cellular energy deficits have been associated with symptoms like fatigue and pain (Sui et al., 2013
The value of this report is not simply that improvement occurred
The recent development of more complex therapies and the extension of interest in the domain of senescence in different fields of research allow to extend the possibility to discover powerful therapies
doi: 10.1016/j.ccr.2009.03.018
