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344 Growing evidence suggests that many therapeutic effects of MSCs may result primarily from the secretion of paracrine factors through EVs rather than direct cellular engraftment and response at the injury site

Vo TTT, Hsu CY, Wee Y, Chen YL, Cheng HC, Wu CZ, et al

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SAC has been shown to decrease the levels of ROS and its neuroprotective effects are mediated predominantly through the caspase-12-dependent pathway in a concentration-dependent manner, but does not prevent the 4-hydroxynonenal-induced death of hippocampal neurons (32)