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Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion

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As a result of an unusually elevated GGT level, patient was advised to avoid alcohol

Roboz G, Pabst T, Aribi A, Brandwein J, Dhner H, Fiedler W, Gandini D, Geddes M, Hou J, Howes A, Hultberg A, Huselton E, Jacobs J, Kane C, Lech-Marada E, Louwers M, Nottage K, Platzbecker U, Rampal R, Salman M, Shah P, Stevens D, Stuart M, Subklewe M, Sumbul A, Wang E, Wierzbowska A, Yao B, Yee, K, Kantarjian H, Borthakur G

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similarly, targeting the intestinal barrier permeability holds promise for therapy and for the prevention of disease