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For instance, under depletion or low glucose concentrations, cells undergo a metabolic switch from aerobic glycolysis to respiratory growth and hexokinase II (HKII), the mitochondria-located enzyme that catalyzes the first step of glycolysis, binds to mTORC1 to inhibit its downstream signaling and induce autophagy 13
ORegan, The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers
doi: 10.1152/physrev.00017.2011 [DOI] [PubMed] [Google Scholar] Wang R, Szabo C, Ichinose F, et al
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Target volume delineation of the neck for radiotherapy in nasopharyngeal carcinoma
Nguyen MH, Duy PN, Dong B, Nguyen TH, Bui CB, Hadinoto K
