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Acyl-CoA synthase long-chain family member 4 (ACSL4) expression correlates with susceptibility, while NO-driven upregulation of heme oxygenase-1 (HMOX1) increases labile iron pools, amplifying lipid peroxidation (122)

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Additionally, therapeutic approaches targeting microbial metabolites, such as SCFA supplementation or modulation of tryptophan metabolism, are under investigation and may offer novel preventive or therapeutic options (Stallmach et al., 2024)

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There is no strong clinical evidence of direct biological antagonism between GHK-Cu and retinol