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The ratio of LC3 II-to-LC3 I, a widely recognized marker of autophagosome formation, was found to be significantly elevated following GHRP-6 treatment in both saline- and DOX-treated skeletal muscle, with increases of approximately 400%

RBM-007, an RNA aptamer designed to target fibroblast growth factor 2 (FGF2), is currently in Phase II clinical trials for treating neovascular AMD (nAMD)

Baseline CAPS scores were also comparable between the improved (mean standard deviation [SD], 27.3 12.4) and non-improved groups (mean SD, 22.6 13.4) (t = 1.24, P = 0.220), reflecting similar demographic and clinical characteristics at baseline

Thus, these data point to a second level of complexity in substrate affinity by zDHHCs, where regions distant from the palmitoylatable Cys might subserve regulatory functions