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Deficiencies in mitochondrial GR activity have been implicated in various neurodegenerative conditions, aging processes, and metabolic disorders

What this means for clinical research: Early clinical programs will enter Phase I faster and with different evidence packages, shifting risk assessment earlier and increasing the importance of translational and modeling capabilities at the clinical interface

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Studies have found that HFD can stimulate pro-inflammatory signaling cascades, increase cytokines (TNF-, IL-1, IL-6, and IFN-) that disrupt the barrier, and decrease cytokines (IL-10, IL-17, and IL-22) that promote barrier formation, thereby enhancing intestinal permeability

[DOI] [PubMed] [Google Scholar] 20.Ates I., Arikan M.F., Altay M., Yilmaz F.M., Yilmaz N., Berker D., Guler S

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