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The ROS species O 2 (superoxide anion), OH (hydroxyl radical), and H 2 O 2 (hydrogen peroxide) are formed by the partial reduction of oxygen and the cellular ROS are formed by endogenous mechanisms like the one in mitochondrial oxidative phosphorylation [27]

For example, piracetam was able to reduce the accumulation of lipofuscin in rat brains

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Vitexin and formononetin are phytochemicals derived from Nelumbo nucifera (lianzixin) and Astragalus membranaceus (Huangqi), respectively

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Fecal microbiota transplantation (FMT) involves transferring fecal matter from a healthy donor to a recipient to restore a healthy gut microbiota
