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This study showed that pelvic irradiation can substantially promote pyknosis in the neurons of DG and CA2 regions of the hippocampus, which strongly supports that pelvic irradiation can cause memory and cognitive effects indirectly

Brain-derived neurotrophic factor signaling mitigates the impact of acute social stress

10.1016/j.cbi.2016.08.018 184 WangM.LiuC

In autoimmune diseases such as systemic lupus erythematosus (SLE), mitochondrial damage and the release of mitochondrial DNA (mtDNA) into the cytoplasm and extracellular space have been observed [130]

For researchers studying tissue repair and regeneration , this anti-fibrotic activity is particularly relevant because fibrosis (excessive scar tissue formation) is often the limiting factor in functional recovery