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First and foremost is the fragility of Vitamin B12

Journal of Strenght and Conditioning Research 2003;17(3):455-462

In summary, while intrinsic TMAO elevation is associated with unfavorable cardiovascular outcomes, inconsistent results of supplementation studies suggest that artificial elevation of TMAO fails to account for all involved mechanisms [72]

Role of carnitine in fatty acid metabolism and deficiency

Patients with diabetes, patients with renal function, mental workers, manual workers, due to the discharge of more waste, the consumption of L-carnitine in the body is large, which can easily lead to the lack of L-carnitine and need long-term supplement

It plays a key role in transporting fatty acids to the mitochondria, where they are converted into energy