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Conclusions Identifying the key regulators of sleep is essential to understanding the detrimental effects on health associated with sleep disruptions

Missing values were imputed, and significantly up- or down-regulated hits were determined by multiple-sample test (one-way ANOVA, s0 = 0.1, FDR = 0.05) and t test (two-sided, s0 = 0.1, FDR = 0.05)

Therefore, non-oral therapies that avoid the gastrointestinal system seem a rational option to overcome the problems of oral therapies in PD

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