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These findings position the compound as a valuable research tool for investigating whether NNMT modulation influences age-associated metabolic changes in mammalian aging models
Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+
The compound's unique mechanism of action simultaneously preserving NAD+ availability and methylation capacity through selective NNMT inhibition offers researchers a powerful approach to investigating metabolic flexibility and cellular adaptation
Molecular Metabolism 45:101165
Mass spectrometry (LC-MS) identity confirmation
