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Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites

Nishimura and colleagues showed that loss of ATM in melanoblast stem cells within the hair follicle bulge region in mice could sensitize the stem cells to genotoxic stress, leading to early differentiation, depletion from the niche and progressive hair greying over subsequent cell cycles due to eventual depletion of mature melanocytes from the hair bulb 3,10

2 Tests 1a to 2b (four tests) were conducted over a two month period

indicates downregulation (decrease)

Some peptides may have relatively short half-lives and leave the bloodstream within hours, while others may remain active for longer periods
