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In the circulation, VLDL is metabolized to the cholesteryl ester-enriched intermediate low-density lipoprotein (IDL) and LDL particles through the progressive hydrolysis of triglycerides by lipoprotein lipase (LPL) and hepatic lipase (Figure 6)
Although there is no close relationship between plasma VPA concentrations and the severity of CNS toxicity [11, 86], patients who ingest more than 200 mg/kg VPA and/or have plasma concentrations greater than 180 g/ml usually develop severe CNS depression
B 120 , 93879394 (2016)
B.SunH.SongY
elegans have shown that the nervous system regulates HSF-1 activity in HSR in a cell non-autonomous manner
Varbo A, Nordestgaard BG