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Author contributions K.Y., K.S.V., S.J., T.C.M.T., and V.S.: resourcing, table creation, and writing the original draft

Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

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5-Amino-1MQ has been associated with beneficial metabolic changes, including improved insulin sensitivity and altered lipid metabolism