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Defects in both UPR signaling and ERAD have been strongly implicated in neurodegenerative diseases, including Alzheimers disease and amyotrophic lateral sclerosis (ALS), highlighting the clinical relevance of maintaining proper ER zinc homeostasis 126,127,128

J Biol Chem 289: 3131031318, 2014 [DOI] [PMC free article] [PubMed] [Google Scholar]

NAC provides cysteine, the building block your body uses to make its own glutathione

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