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Notably, MDD patients show elevated OGT mRNA levels, and Ogt expression in astroglia is upregulated in the mPFC of susceptible mice following chronic social-defeat stress (CSDS)

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Sex-related molecular markers of MDD Women are more likely than males to experience recurring MDD 445 and are twice as likely to experience MDD throughout their lifetimes

Another study also showed that gp120 alone or together with methamphetamine activate NLRP3 and promote inflammatory response in microglia [37, 119]

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