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Description
Particularly in tumor cells with active glycolysis, accumulated lactate stabilizes and increases the activity of proglycolytic transcription factors such as HIF-1 and c-Myc, as well as the expression of their downstream target genes, via lactylation, thereby forming a self-reinforcing positive feedback loop that further entrenches the glycolytic phenotype of tumors [78, 79]
Zhu F, Li W, Zhou X, Chen X, Zheng M, Cui Y, Liu X, Guo X, Zhu H (2021) PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice
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Fruhwirth GO, Moumtzi A, Loidl A, Ingolic E, Hermetter A
Preventing the transmission of mitochondrial DNA disorders using prenatal or preimplantation genetic diagnosis
doi: 10.3233/JND-200475
