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10.1038/nrn.2015.19 145

Another significant obstacle is the permeability of the bloodbrain barrier, as many small compounds that demonstrate strong in vitro efficacy have limited exposure to the central nervous system (CNS) in vivo, necessitating high doses that may increase systemic toxicity

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Our previous work has shown that IM injection of prototype BPC157 can effectively promote wound healing, and we aim to conduct clinical trials examining BPC157 for the treatment of severe trauma and burns in China

Nausea, especially during dose escalation, affects a significant percentage of users

The subcellular localization of eNOS influences the degree of S-nitrosylation, with membrane-bound eNOS being more heavily nitrosylated than its cytosolic counterpart due to higher NO production at the membrane (Erwin et al., 2006)