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Transgenic mice with multiple MT-I genes, have 1020 fold greater MT protein levels in the pancreas, liver and stomach, and 26 fold greater MT levels in a number of other organs including kidney, spleen and heart [17]

With the help of proteomics, oxidative modifications to glycolytic enzymes, ATP synthase, -enolase, aconitase (enzyme containing iron-sulfur core), creatine kinase (maintains ATP levels in neurons), and other enzymes have been identified (Butterfield and Boyd-Kimball 2018)

Cell Mol Life Sci 62:17071723

Prevention and Control of Hypertension: JACC Health Promotion Series

However, many important questions remain unresolved

The expression of the pregnane X receptor (PXR) in the liver was significantly upregulated, correlating with BA accumulation and promoting lipid synthesis (106, 107)