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Nature 584, 437442

Salidroside, a natural phenylpropanoid glycoside isolated from Rhodiola rosea , has been shown to enhance mitochondrial complex I activity by upregulating and phosphorylating AMPK2, increasing cardiomyocyte tolerance to I/R injury and reducing ferroptosis

These reductions may result from a direct effect on presynaptic 1 AR, facilitating release of norepinephrine and epinephrine
